Proteomics Is Analytical Chemistry: Fitness-for-Purpose in the Application of Top-Down and Bottom-Up Analyses

Proteomics Is Analytical Chemistry: Fitness-for-Purpose in the Application of Top-Down and Bottom-Up Analyses

Molecular mechanisms underlying health and disease function at least in part based on the flexibility and fine-tuning afforded by protein isoforms and post-translational modifications. The ability to effectively and consistently resolve these protein species or proteoforms, as well as assess quantitative changes is therefore central to proteomic analyses. Here we discuss the pros and cons of cu...

Bottom-up, top-down

Flipped Top-Down is Systematic Bottom-Up

The paper presents an experience report in course design for a versatile group of computer science students where their needs were surfaced and met by the combination of strict top-down exposure to course material and the flipped classroom model of lecturing.

Top - Down ? CHEMISTRY : Mass Spectrometry : Bottom - Up or

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Event-Related Potentials of Bottom-Up and Top-Down Processing of Emotional Faces

Introduction: Emotional stimulus is processed automatically in a bottom-up way or can be processed voluntarily in a top-down way. Imaging studies have indicated that bottom-up and top-down processing are mediated through different neural systems. However, temporal differentiation of top-down versus bottom-up processing of facial emotional expressions has remained to be clarified. The present st...